Epilepsy: New treatments and local expertise

For those living with epilepsy, access to expert care and the latest treatment options can make all the difference. In West Michigan, patients receive nationally recognized epilepsy care at our Level IV Epilepsy Center, the highest possible designation from the National Association of Epilepsy Centers that recognizes our ability to provide the most complex forms of care and treatment.

Anti-seizure medication updates

The landscape of epilepsy treatment has evolved in recent years. Between 2019 and 2025, the FDA approved several new anti-seizure medications that have fewer long-term side effects. These medications are designed to target specific mechanisms in the brain, allowing for more personalized and effective treatment plans.

Cenobamate, approved in 2019, is one of these breakthroughs. This medication is used to treat focal epilepsy, a type of seizure that starts in one part of the brain. It helps calm overactive brain signals by boosting the effects of a natural calming chemical called GABA and by blocking certain pathways (sodium channels). Clinical trials showed that up to 20% of patients became seizure-free with this medication, and there is ongoing research for using this medication in patients with generalized epilepsy.

“Cenobamate has been a game-changer for many of our patients,” said Desiree Markantone, MD, a fellowship-trained epileptologist with Trinity Health Medical Group in Grand Rapids. “It’s exciting to see such high seizure-free rates, especially in individuals who’ve struggled for years to find relief.”

Another promising medication is Fenfluramine. Fenfluramine was once used as a weight-loss drug, but it’s now showing promise in treating certain types of epilepsy. It works by increasing serotonin levels in the brain, a chemical that helps regulate mood and nervous system activity. In children with severe seizure disorders such as Dravet syndrome, studies have shown that fenfluramine not only reduces the number of seizures but may also lower the risk of Sudden Unexpected Death in Epilepsy (SUDEP), a rare but serious complication. This gives new hope to families facing the challenges of hard-to-treat epilepsy.

For patients with focal seizures, Lacosamide XR, offers a convenient extended-release option with fewer side effects and improved seizure control.

Rescue therapies: fast relief when it’s needed most

In addition to daily medications, rescue therapies play a critical role in managing acute seizure episodes. Two intranasal options, Midazolam and Diazepam, have transformed emergency seizure care.

These fast-acting sprays can be administered by caregivers or family members, helping to stop seizure clusters quickly and safely. They offer peace of mind and reduce the need for emergency room visits.

“Having access to rescue therapies is empowering for families,” Dr. Markantone explains. “It means they can act quickly and confidently during a seizure emergency, often avoiding a trip to the ER.”

Local care, national expertise

“We’re proud to offer a full-service epilepsy program right here in West Michigan,” says Dr. Markantone “Our team is deeply committed to helping patients find the right treatment and live their lives with confidence.”

With new medications, advanced therapies and a dedicated team, Trinity Health is helping patients live fuller, safer lives right here in their community.

Learn more about epilepsy care at Trinity Health Michigan.